1. Kahler JP, Ellenbroek B, van der Noord V, van de Water B, Pomplun SJ: ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors, Chem (2025) 12 (4).
doi: 10.1016/j.chempr.2025.102839
2. Ellenbroek B, Kahler JP*; Arella D, Lin C, Jespers W, Züger EAK, Drukker M, Pomplun SJ: Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC, Angewandte Chemie International Edition (2025) 64 (4).
doi: 10.1002/anie.202416082
3. Kahler JP, Ji S, Speelman-Rooms F, Vanhoutte R, Verhelst SHL: Phosphinate Esters as Novel Warheads for Quenched Activity-based Probes Targeting Serine Proteases, ACS Chemical Biology (2024) 19 (7): 1409-1415.
doi: 10.1021/acschembio.3c00203
4. Ellenbroek B; Kahler JP*, Evers SR, Pomplun SJ: Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids, Angewandte Chemie International Edition (2024) 63 (20).
doi: 10.1002/anie.202401704
5. Sukhbaatar N, Schöller M, Fritsch SD, Linke M, Horer S, Träger M, Mazić M, Forisch S, Gonzales K, Kahler JP, Binder C, Lassnig C, Strobl B, Müller M, Scheiber-Mojdehkar B, Gundacker C, Dabsch S, Kain R, Hengstschläger M, Verhelst SHL, Weiss G, Theurl I, Weichhart T: Duodenal macrophages control dietary iron absorption via local degradation of transferrin, Blood (2023) 141 (23): 2878-2890.
doi: 10.1182/blood.2022016632
6. Kahler JP, Aloi, VD, Miedes Aliaga J, Kerselaers S, Voets T, Vriens J, Verhelst SHL, Barniol-Xicota M: Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship, ACS Chemical Biology (2023) 18 (3): 456-464.
doi: 10.1021/acschembio.2c00672
7. Yang J, Korovesis D, Ji S, Kahler JP, Vanhoutte R, Verhelst SJL: Efficient Synthesis of an Alkyne Fluorophosphonate Activity-Based Probe and Applications in Dual Colour Serine Hydrolase Labelling, Israel Journal of Chemistry (2023) 63 (3-4).
doi: 10.1002/ijch.202200094
8. Kahler JP; Verhelst SHL: Phosphinate esters as novel warheads for activity-based probes targeting serine proteases, RSC Chemical Biology (2021) 2 (4): 1285-1290.
doi: 10.1021/acschembio.2c00672
9. Kahler JP, Lenders S, van de Plassche MAT, Verhelst SHL: Facile Synthesis of Aminomethyl Phosphinate Esters as Serine Protease Inhibitors with Primed Site Interaction, ACS Medicinal Chemistry Letters (2020) 11 (9): 1739-1744.
doi: 10.1021/acsmedchemlett.0c00284
10. Kahler JP; Vanhoutte R; Verhelst SHL: Activity-Based Protein Profiling of Serine Proteases in Immune Cells, Archivum immunologiae et therapiae experimentalis (2020) 68 (23).
doi: 10.1007/s00005-020-00586-2
11. Van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P: ATP13A2 deficiency disrupts lysosomal polyamine export, Nature (2020) 578: 419-424.
doi: 10.1038/s41586-020-1968-7
12. Chakrabarty S; Kahler JP*; van de Plassche MAT; Vanhoutte R; Verhelst SHL: Recent Advances in Activity-Based Protein Profiling of Proteases, Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 420).
doi: 10.1007/82_2018_138
13. Vanhoutte R; Kahler JP*; Martin S; van Veen S; Verhelst SHL: Clickable Polyamine Derivatives as Chemical Probes for the Polyamine Transport System, ChemBioChem (2018) 19 (907): 907-911.
doi: 10.1002/cbic.201800043